OPP Method
ROI Calculator

Calculate the active ingredient potency your brand is losing to heat degradation in conventional manufacturing — and what the One Pot Process (OPP) Method delivers instead. All degradation rates sourced from published peer-reviewed data.

📊

Peer-Reviewed Data

All degradation rates cited

🔬

OPP Patent Pending

AU 2026901796

💡

Shareable Results

Copy & share on LinkedIn

🏭

GMP Certified

ISO 22716 · SGS

🇦🇺

Australian Made

Ravenhall VIC 3023

Your Formulation Details

Step 1 — Primary Heat-Sensitive Active

Active Ingredient Type

Select your primary heat-sensitive active. Degradation rates sourced from peer-reviewed literature.

Target Concentration (%)

What concentration are you targeting on label?

Ingredient Cost per kg (AUD $)

What does your active ingredient cost per kg?

Step 2 — Batch & Business Details

Batch Size (kg)

50 kg

Batches per Year

12 /yr

Finished Product Price per Unit (AUD $)

Units per kg of finished product

e.g. 30ml serum ≈ 33 units/kg

Degradation Rate Sources

Retinol: Temova Rakuša et al. (2020) J. Cosmetic Dermatology DOI:10.1111/jocd.13852 — 40–100% at 40°C
Peptides: GHK-Cu formulation data: never exceed 40°C. Biochemical: DSC studies confirm peptide denaturation 38.5–50°C
Postbiotics: PMC10572142 — enzyme activity affected at emulsification temps; PMC12639491 — SCFA release decreased 65–95°C
Live probiotics: Fundamental microbiology — killed above 37°C (complete)
Astaxanthin: PMC11582459 (2024) — significant degradation above 60°C. Springer (2016) — rate constant increases with temperature
OPP enhancement: Zhang et al. (2017) PMID 28763230 — 33× in vitro, 72× in vivo

Your Results

Based on peer-reviewed degradation data & OPP enhancement factors

Actual Active Potency Delivered to Product

Conventional Hot-Process

0.5%

actual potency preserved

OPP Cold-Process

5.0%

actual potency preserved

Potency lost to heat (per batch)—

Active ingredient cost wasted (per batch)—

Annual active ingredient waste—

OPP transdermal enhancement (in vitro) 33×

Effective skin penetration — conventionalSurface only

Effective skin penetration — OPPSub-epidermal

Annual revenue (at your unit price)—

Est. annual value of switching to OPP —

Enter your details to see your personalised ROI insight.

All degradation percentages are sourced from published peer-reviewed research. Individual actives vary by formulation, pH, antioxidant system and packaging. OPP transdermal enhancement: 33× in vitro, 72× in vivo (Zhang et al., PMID 28763230). This calculator provides estimates for illustration and business planning purposes only — not a guarantee of specific results. Annual value estimate includes ingredient waste recovery and estimated 20% OPP premium pricing uplift.

Methodology & Data Sources

The Science Behind
These Numbers

Heat Degradation Data

Retinol: 40–100% at 40°C (Temova Rakuša et al., J. Cosmetic Dermatology, 2020). Peptides: above 40–50°C (established biochemistry, GHK-Cu formulation data). Astaxanthin: significant above 60°C (PMC11582459, 2024). Postbiotic enzyme activity: affected at 65–95°C (PMC12639491). Live probiotics: killed above 37°C (fundamental microbiology).

OPP Enhancement Factor

33× baseline (in vitro porcine skin) and 72× in vivo figures from Zhang et al. (2017), Molecular Pharmaceutics, PMID 28763230. 73.4% human dermal absorption from PMC12564063 (2025 clinical trial). These are the primary peer-reviewed foundations for all OPP delivery claims.

Important Limitations

Ferment lysate degradation rates reflect enzymatic bioactivity loss — not total lysate destruction (lysates are already heat-killed during production). Astaxanthin degradation is significant above 60°C (not 40°C). All figures are representative ranges. Individual formulations vary based on pH, antioxidants, packaging and processing time.

Ready to Switch?

Stop Paying for Actives
That Never Reach the Skin

Get a custom manufacturing quote based on your specific active brief. NDA before any technical discussion.

Get A Manufacturing Quote OPP Technology Deep-Dive

OPP MethodROI Calculator