Every GlowSense product is manufactured using the patent-pending One Pot Process (OPP) Method — a cold-process single-vessel co-formulation that preserves and delivers heat-sensitive actives at concentrations and skin depths unachievable by conventional manufacturing.
No active degradation from heat
33–91× transdermal enhancement
ISO 22716 · SGS certified
Ravenhall, Victoria
Every batch documented
Each product in the GlowSense range is manufactured using the One Pot Process (OPP) Method — combining marine bio-spicules and heat-sensitive actives in a single cold-process vessel to achieve genuine sub-epidermal delivery that conventional manufacturing cannot replicate.
Scalp Treatment · 50ml · OPP Delivery
A high-concentration triple peptide complex delivered via the One Pot Process directly to the hair follicle dermis. All three active peptides are heat-labile above 45°C — completely denatured in any conventional hot-process formulation. Cold-process manufacture is essential for this formula to function as claimed.
Face Serum · 30ml · OPP Delivery
Niacinamide at 10% co-formulated cold-process with a signal peptide complex and Haliclona sp. bio-spicules. Research confirms niacinamide degrades above 60–70°C, converting to nicotinic acid. OPP microchannels enable sub-epidermal delivery of both niacinamide and its co-active peptides — impossible in conventional formulations where peptides would be destroyed.
Face Serum · 30ml · OPP Delivery
Sodium Ascorbyl Phosphate (SAP) co-formulated cold-process with bio-spicules for genuine transdermal brightening. SAP undergoes accelerated oxidative degradation above 40°C during standard manufacturing. Cold-process eliminates all thermal oxidation from batch to shelf, while OPP delivers SAP sub-epidermally for collagen synthesis stimulation at the fibroblast layer.
Cleanser · 150ml · Sulphate-Free
SCI (Sodium Cocoyl Isethionate) based sulphate-free foam cleanser with prebiotic and postbiotic actives. Cold-process is essential: postbiotic ferment lysate enzymes are heat-denatured above 37°C, and FOS prebiotic oligosaccharide chains degrade under sustained heat. Live postbiotic activity cannot be preserved by any hot-process route.
Dry Powder Mask · Compostable Pouch
A minimal 5-ingredient dry powder formulation — preservative-free by format design. Kaolin Clay for deep pore cleansing, Moringa for antioxidant delivery, Colloidal Oatmeal for barrier soothing. Mix with water to activate. The dry format eliminates the need for synthetic preservatives while preserving full botanical potency.
Any format · Any active · OPP or conventional
Bring your active brief. We design a bespoke One Pot Process formulation for your target actives, format and brand positioning. Every engagement is covered by NDA before any technical discussion. MOQ from 500 units.
The One Pot Process (OPP) Method addresses heat sensitivity at three levels: actives that are completely destroyed by conventional heat; actives that lose significant efficacy above 40–60°C; and actives that are individually stable but can only be meaningfully co-formulated with other heat-sensitive actives via cold-process. All claims below are grounded in published scientific literature.
Peptide tertiary structure is irreversibly denatured above 40–50°C. No hot-process manufacturing route can preserve their biological activity.
Collagen and elastin-stimulating peptides. Denatured above 45–50°C. OPP cold-process preserves full peptide chain integrity and delivers them sub-epidermally via bio-spicule microchannels to target fibroblasts directly.
Destroyed above 45–50°CSNARE complex inhibitors that reduce muscle contraction and fine lines. Heat-labile peptide bonds. OPP bio-spicule delivery enables genuine sub-epidermal access to neuromuscular targets in the dermis.
Destroyed above 40–45°CCopper disassociates from the peptide bond under heat, destroying biological activity. Cold-process OPP preserves the intact copper-peptide complex for wound repair signalling, collagen synthesis and follicle anchoring.
Copper bond destroyed by heatDHT-inhibiting peptide complex for scalp applications. Heat-labile above 45°C. OPP delivers the intact complex via bio-spicule microchannels directly to the hair follicle dermis — the target depth conventional serums cannot reach.
Destroyed above 45°CProtein-based growth factors that stimulate keratinocyte and fibroblast activity. Denatured by heat AND too large for passive transdermal penetration. OPP simultaneously solves both the manufacturing and the skin delivery barrier.
Protein denaturation above 37–45°CProtein-derived bioactive fractions. Thermal denaturation reduces biological activity. OPP bio-spicule delivery overcomes the passive diffusion barrier for fragments too large to penetrate the stratum corneum.
Protein structure denatured by heatEnzymes are denatured above 37–40°C. Live cultures are killed above 37°C. These actives are completely incompatible with any hot-process manufacturing.
Enzymatic antioxidant that neutralises superoxide radicals responsible for oxidative skin ageing. Denatured above 40°C. Cold-process OPP is the only manufacturing method that can deliver active SOD in a finished cosmetic product.
Enzyme denatured above 40°CBacterial and algae-derived enzymes that reverse UV-induced DNA damage (thymine dimers). All heat-labile proteins. Cold-process OPP is the only viable manufacturing route for active DNA repair enzyme cosmetics.
Enzyme denatured above 40°CBioactive fermentation byproducts including enzymes, antimicrobial peptides and short-chain fatty acids. NIH research confirms heat-killing results in enzyme inactivation and protein coagulation, directly impairing immunomodulatory activity. Cold-process is the only viable route.
Enzyme activity destroyed by heatNatural-origin postbiotic and antimicrobial active from radish fermentation. Full enzyme and peptide activity is destroyed by heat. Cold-process OPP preserves the complete antimicrobial and skin-conditioning ferment fraction.
Bioactive ferment destroyed by heatLive beneficial bacteria for topical microbiome restoration. Killed above 37°C — completely incompatible with any hot-process manufacturing. Cold-process low-water OPP systems are the only viable route for genuinely live probiotic cosmetics.
Killed above 37°CMesenchymal stem cell-derived nanovesicles containing growth factors, miRNA and signalling proteins. Completely heat-denatured. Clinical data (PMC12564063, 2025) confirms spicule-mediated secretome delivery achieves 73.4% dermal absorption in human subjects.
Completely heat-denatured · 73.4% human dermal absorptionPublished peer-reviewed data confirms major activity loss at emulsification temperatures. Cold-process preserves full potency from batch to shelf.
All Vitamin C derivatives undergo accelerated oxidative degradation above 40°C. Sodium Ascorbyl Phosphate (SAP), the most stable form, still degrades significantly during hot-process emulsification. Cold-process OPP preserves 100% activity and delivers sub-epidermally for collagen synthesis stimulation.
Oxidative degradation above 40°CPublished peer-reviewed data (Wiley, Journal of Cosmetic Dermatology, 2020) confirms 40–100% retinol degradation at 40°C and thermal isomerisation of all-trans-retinol to inactive 13-cis-retinol. Cold-process OPP eliminates all thermal exposure and enables bio-spicule-assisted transdermal delivery.
40–100% degradation at 40°C (published data)Marine carotenoid — one of nature's most potent antioxidants. Degrades rapidly above 40°C via oxidative cleavage of the conjugated double bond system. Cold-process OPP is the only viable manufacturing route for any astaxanthin formulation making credible efficacy claims.
Rapid degradation above 40°CPlant-based retinol alternative. Undergoes thermo-oxidation above 40°C, losing its retinoid-mimetic biological activity. Cold-process OPP preserves 100% of bakuchiol activity and delivers it to retinoid-equivalent epidermal depth without the irritation profile of retinol itself.
Thermo-oxidation above 40°CStilbenoid polyphenol with anti-inflammatory and anti-ageing activity via sirtuin pathway activation. Thermal and oxidative degradation above 45°C converts active trans-resveratrol to inactive cis-resveratrol. Cold-process OPP preserves the active isomer and delivers it sub-epidermally.
Trans-to-cis isomerisation above 45°CPolyphenol catechins with anti-inflammatory and antioxidant activity. Catechin epimerisation and oxidation is accelerated above 50°C, converting bioactive catechins to inactive epimers. Cold-process preserves the active trans-catechin configuration for OPP sub-epidermal delivery.
Epimerisation above 50°CResearch confirms niacinamide degrades above 60–70°C, converting to nicotinic acid — causing the characteristic "niacinamide flush." Cold-process OPP prevents any thermal conversion and enables co-formulation with heat-sensitive peptide co-actives in a single batch, delivering both sub-epidermally.
Converts to nicotinic acid above 60–70°CFat-soluble mitochondrial antioxidant. Undergoes oxidative degradation during hot-process emulsification, reducing its antioxidant capacity. Cold-process OPP preserves full CoQ10 redox activity and enables OPP bio-spicule delivery to mitochondria-rich keratinocytes and fibroblasts.
Oxidative degradation during emulsificationPhenolic antioxidant that doubles the efficacy of Vitamins C and E when co-formulated. Photo- and thermo-oxidised above 45°C, losing its Vitamin C-stabilising synergy. Cold-process OPP is essential for ferulic acid to fulfil its role as a Vitamin C co-antioxidant in any OPP brightening formula.
Photo- and thermo-oxidation above 45°CTyrosinase inhibitor from fungal fermentation (Aspergillus, Penicillium). Highly heat and light sensitive — oxidises and discolours during hot-process manufacture, forming oxidative breakdown products. Cold-process OPP preserves Kojic Acid activity for genuine tyrosinase inhibition at the melanocyte layer.
Oxidation and discolouration during emulsificationCellular energy coenzymes with proven anti-ageing activity via sirtuin pathway activation. NAD+ is thermolabile and degrades in the presence of heat. Cold-process OPP preserves the intact NAD+ molecule for topical delivery, enabling a new generation of cellular energy skincare.
Thermolabile · Degrades with heatHeat-labile biological complexes containing epigenetic signalling compounds, phytohormones and stress proteins. Conventional emulsification destroys the biological complexity that gives plant stem cell extracts their activity. Cold-process OPP preserves and delivers the full extract complexity below the stratum corneum.
Biological complexity destroyed by heatThese actives have varying heat sensitivity — from partial degradation risk to stable actives that benefit specifically from being co-formulated cold-process alongside Tier 1 and Tier 2 actives.
Selectively promotes Lactobacillus and Bifidobacterium on skin while preventing Staphylococcus aureus colonisation. Oligosaccharide chain structure degrades under sustained heat, reducing prebiotic selectivity. Cold-process OPP ensures intact prebiotic oligosaccharides reach the skin microbiome.
Oligosaccharide chain degradation under heatShort-chain prebiotic oligosaccharides that selectively feed beneficial skin flora. FOS undergoes caramelisation and chain degradation under sustained heat, reducing prebiotic efficacy. Cold-process OPP maintains full chain integrity and enables true synbiotic (prebiotic + postbiotic) co-formulations.
Caramelisation and chain degradation under heatResearch confirms HA can undergo thermal depolymerisation at elevated temperatures, reducing molecular weight from HMW (surface film-forming) to LMW (deeper penetrating) forms — changing the product's skin behaviour unintentionally. Cold-process preserves the intended molecular weight profile throughout manufacture.
Thermal depolymerisation risk at elevated tempBioactive triterpenes with wound healing and collagen synthesis activity. Heat-sensitive — triterpene bioavailability and activity are reduced at emulsification temperatures. Cold-process OPP preserves the full madecassoside and asiaticoside fraction for sub-epidermal delivery to collagen-producing fibroblasts.
Activity reduced at emulsification temperatureGlycoside tyrosinase inhibitor. Research confirms alpha-arbutin is best added below 50°C to ensure maximum potency and prevent any risk of hydroquinone conversion. Cold-process OPP ensures zero thermal risk and enables co-formulation with Kojic Acid, Vitamin C derivatives and peptides in a single batch for multi-pathway pigmentation correction.
Best below 50°C · OPP enables multi-active brighteningNatural ceramides require 60°C+ for conventional emulsification. This processing temperature is incompatible with any co-formulated heat-sensitive actives. Cold-process self-emulsifying systems enable ceramide co-formulation with intact peptides, postbiotics and growth factors simultaneously in one OPP batch.
OPP enables ceramide + peptide + postbiotic systemsDual-function active: prebiotic for beneficial skin microbiome and soothing active via macrophage activation. High molecular weight beta-glucan can undergo thermal depolymerisation, reducing both prebiotic activity and immune modulation efficacy. Cold-process preserves full molecular weight and biological activity.
Thermal depolymerisation reduces MW and efficacyCold-pressed oils rich in conjugated linolenic acids (CLnA), omega fatty acids and fat-soluble antioxidants. Oxidation and PUFA (polyunsaturated fatty acid) degradation is dramatically accelerated by heat. Cold-process OPP enables full-concentration use of the most potent cold-pressed botanicals without any oxidative loss.
PUFA oxidation accelerated by heatRelatively heat-stable brightening actives. Their primary OPP benefit is co-formulation: combining tranexamic acid and azelaic acid in a single cold-process batch with heat-sensitive peptides, Vitamin C derivatives and postbiotics creates multi-pathway pigmentation correction systems that cannot be produced any other way.
Stable but OPP enables multi-active co-formulationThe physical delivery mechanism that defines the One Pot Process. Patent Pending · AU 2026901796 · Zero global prior art confirmed.
The physical delivery vector of the OPP Method. Upon topical application, silica spicules (∼120 µm length, ∼7 µm diameter) create transient microchannels in the stratum corneum. Self-limiting — skin fully recovers (TEWL confirmed, Zhang et al. 2017). Spicules retained 72hr as sustained-release depots. Peer-reviewed data: 33× in vitro, 72× in vivo, 15× vs. Dermaroller.
Patent Pending AU 2026901796 · Zero global prior artThe OPP Method is not just a delivery system — it is a manufacturing process. All ingredients including bio-spicules and target actives are combined in a single vessel at ambient temperature. No heating phase. No separate cooling phase. No active degradation from manufacture. This is the patented innovation: the cold-process single-vessel co-formulation method itself.
The patented process · AU 2026901796A 2025 human clinical trial (PMC12564063) confirmed spicule-mediated delivery achieves 73.4% dermal absorption of secretome actives in human subjects — significantly higher than uncoated controls. This is the most recent peer-reviewed clinical validation of bio-spicule transdermal delivery in humans, directly supporting the OPP platform's delivery mechanism.
Peer-reviewed clinical data · Human subjects confirmedBring your active brief. Every engagement is NDA-protected. We'll tell you exactly what the One Pot Process can achieve for your specific active combination — and what peer-reviewed data supports it.